Pharmacovigilance in juvenile idiopathic arthritis patients treated with biologic or synthetic drugs: combined data of more than 15,000 patients from Pharmachild and national registries
Identifieur interne : 001259 ( Main/Exploration ); précédent : 001258; suivant : 001260Pharmacovigilance in juvenile idiopathic arthritis patients treated with biologic or synthetic drugs: combined data of more than 15,000 patients from Pharmachild and national registries
Auteurs : Joost Swart [Pays-Bas] ; Gabriella Giancane [Italie] ; Gerd Horneff [Allemagne] ; Bo Magnusson [Suède] ; Michael Hofer [Suisse] ; Katerina Alexeeva [Russie] ; Violeta Panaviene [Lituanie] ; Brigitte Bader-Meunier [France] ; Jordi Anton [Espagne] ; Susan Nielsen [Danemark] ; Fabrizio De Benedetti [Italie] ; Sylvia Kamphuis [Pays-Bas] ; Valda Sta Vi A ; Maria Tracahana [Grèce] ; Laura Marinela Ailioaie [Roumanie] ; Elena Tsitsami [Grèce] ; Ariane Klein [Allemagne] ; Kirsten Minden [Allemagne] ; Ivan Foeldvari [Allemagne] ; Johannes Peter Haas [Allemagne] ; Jens Klotsche [Allemagne] ; Anna Carin Horne [Suède] ; Alessandro Consolaro [Italie] ; Francesca Bovis [Italie] ; Francesca Bagnasco [Italie] ; Angela Pistorio [Italie] ; Alberto Martini [Italie] ; Nico Wulffraat [Pays-Bas] ; Nicolino Ruperto [Italie]Source :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2018.
Abstract
The availability of methotrexate and the introduction of multiple biological agents have revolutionized the treatment of juvenile idiopathic arthritis (JIA). Several international and national drug registries have been implemented to accurately monitor the long-term safety/efficacy of these agents. This report aims to present the combined data coming from Pharmachild/PRINTO registry and the national registries from Germany (BiKeR) and Sweden.
Descriptive statistics was used for demographic, clinical data, drug exposure, adverse events (AEs) and events of special interest (ESIs). For the Swedish register, AE data were not available.
Data from a total of 15,284 patients were reported: 8274 (54%) from the Pharmachild registry and 3990 (26%) and 3020 (20%) from the German and the Swedish registries, respectively. Pharmachild children showed a younger age (median of 5.4 versus 7.6 years) at JIA onset and shorter disease duration at last available visit (5.3 versus 6.1–6.8) when compared with the other registries. The most frequent JIA category was the rheumatoid factor–negative polyarthritis (range of 24.6–29.9%). Methotrexate (61–84%) and etanercept (24%–61.8%) were the most frequently used synthetic and biologic disease-modifying anti-rheumatic drugs (DMARDs), respectively. There was a wide variability in glucocorticoid use (16.7–42.1%). Serious AEs were present in 572 (6.9%) patients in Pharmachild versus 297 (7.4%) in BiKeR. Infection and infestations were the most frequent AEs (29.4–30.1%) followed by gastrointestinal disorders (11.5–19.6%). The most frequent ESIs were infections (75.3–89%).
This article is the first attempt to present a very large sample of data on JIA patients from different national and international registries and represents the first proposal for data merging as the most powerful tool for future analysis of safety and effectiveness of immunosuppressive therapies in JIA.
The Pharmachild registry is registered at
The online version of this article (10.1186/s13075-018-1780-z) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13075-018-1780-z
PubMed: 30587248
PubMed Central: 6307151
Affiliations:
- Allemagne, Danemark, Espagne, France, Grèce, Italie, Lituanie, Pays-Bas, Roumanie, Russie, Suisse, Suède
- Attique (région), Berlin, Canton de Vaud, Catalogne, District de Cologne, District fédéral central, Hambourg, Hollande-Méridionale, Hovedstaden, Latium, Rhénanie-du-Nord-Westphalie, Utrecht (province), Île-de-France
- Athènes, Barcelone, Berlin, Copenhague, Hambourg, Lausanne, Moscou, Paris, Rome, Rotterdam, Sankt Augustin, Utrecht
- Université de Barcelone
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Le document en format XML
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Lupu str.nr. 62, Iasi, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>V. 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Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Berlin</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff22"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2218 4662</institution-id><institution-id institution-id-type="GRID">grid.6363.0</institution-id><institution>Charité University Medicine,</institution></institution-wrap>Charitéplatz 1, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charitéplatz 1, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Foeldvari, Ivan" sort="Foeldvari, Ivan" uniqKey="Foeldvari I" first="Ivan" last="Foeldvari">Ivan Foeldvari</name><affiliation wicri:level="3"><nlm:aff id="Aff23">Hamburg Centre for Pediatric and Adolescent Rheumatology, Dehnhaide 120, Hamburg, Germany</nlm:aff><country 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xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Consolaro, Alessandro" sort="Consolaro, Alessandro" uniqKey="Consolaro A" first="Alessandro" last="Consolaro">Alessandro Consolaro</name><affiliation wicri:level="1"><nlm:aff id="Aff25">IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, via Gaslini 5, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, via Gaslini 5, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff26"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2151 3065</institution-id><institution-id institution-id-type="GRID">grid.5606.5</institution-id><institution>Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI),</institution><institution>Università degli Studi di Genova,</institution></institution-wrap>Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Genoa</wicri:regionArea></affiliation></author><author><name sortKey="Bovis, Francesca" sort="Bovis, Francesca" uniqKey="Bovis F" first="Francesca" last="Bovis">Francesca Bovis</name><affiliation wicri:level="1"><nlm:aff id="Aff2">IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa</wicri:regionArea><wicri:noRegion>16147 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Bagnasco, Francesca" sort="Bagnasco, Francesca" uniqKey="Bagnasco F" first="Francesca" last="Bagnasco">Francesca Bagnasco</name><affiliation wicri:level="1"><nlm:aff id="Aff2">IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa</wicri:regionArea><wicri:noRegion>16147 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Pistorio, Angela" sort="Pistorio, Angela" uniqKey="Pistorio A" first="Angela" last="Pistorio">Angela Pistorio</name><affiliation wicri:level="1"><nlm:aff id="Aff27">IRCCS Istituto Giannina Gaslini, Servizio di Epidemiologia e Biostatistica, via Gaslini 5, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Servizio di Epidemiologia e Biostatistica, via Gaslini 5, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Martini, Alberto" sort="Martini, Alberto" uniqKey="Martini A" first="Alberto" last="Martini">Alberto Martini</name><affiliation wicri:level="1"><nlm:aff id="Aff28">IRCCS Istituto Giannina Gaslini, Direzione Scientifica, via Gaslini 5, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Direzione Scientifica, via Gaslini 5, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Wulffraat, Nico" sort="Wulffraat, Nico" uniqKey="Wulffraat N" first="Nico" last="Wulffraat">Nico Wulffraat</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0620 3132</institution-id><institution-id institution-id-type="GRID">grid.417100.3</institution-id><institution>Department of Pediatric Immunology and Rheumatology,</institution><institution>Wilhelmina Children’s Hospital,</institution></institution-wrap>Lundlaan, 6 PO box 85090, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Lundlaan, 6 PO box 85090, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Ruperto, Nicolino" sort="Ruperto, Nicolino" uniqKey="Ruperto N" first="Nicolino" last="Ruperto">Nicolino Ruperto</name><affiliation wicri:level="1"><nlm:aff id="Aff2">IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa</wicri:regionArea><wicri:noRegion>16147 Genoa</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30587248</idno><idno type="pmc">6307151</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307151</idno><idno type="RBID">PMC:6307151</idno><idno type="doi">10.1186/s13075-018-1780-z</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000194</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000194</idno><idno type="wicri:Area/Pmc/Curation">000194</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000194</idno><idno type="wicri:Area/Pmc/Checkpoint">000C45</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C45</idno><idno type="wicri:Area/Ncbi/Merge">001D40</idno><idno type="wicri:Area/Ncbi/Curation">001D40</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D40</idno><idno type="wicri:doubleKey">1478-6354:2018:Swart J:pharmacovigilance:in:juvenile</idno><idno type="wicri:Area/Main/Merge">001258</idno><idno type="wicri:Area/Main/Curation">001259</idno><idno type="wicri:Area/Main/Exploration">001259</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pharmacovigilance in juvenile idiopathic arthritis patients treated with biologic or synthetic drugs: combined data of more than 15,000 patients from Pharmachild and national registries</title><author><name sortKey="Swart, Joost" sort="Swart, Joost" uniqKey="Swart J" first="Joost" last="Swart">Joost Swart</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0620 3132</institution-id><institution-id institution-id-type="GRID">grid.417100.3</institution-id><institution>Department of Pediatric Immunology and Rheumatology,</institution><institution>Wilhelmina Children’s Hospital,</institution></institution-wrap>Lundlaan, 6 PO box 85090, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Lundlaan, 6 PO box 85090, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Giancane, Gabriella" sort="Giancane, Gabriella" uniqKey="Giancane G" first="Gabriella" last="Giancane">Gabriella Giancane</name><affiliation wicri:level="1"><nlm:aff id="Aff2">IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa</wicri:regionArea><wicri:noRegion>16147 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Horneff, Gerd" sort="Horneff, Gerd" uniqKey="Horneff G" first="Gerd" last="Horneff">Gerd Horneff</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Asklepios Clinic Sankt Augustin, Arnold-Janssen strasse 29, Sankt Augustin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Asklepios Clinic Sankt Augustin, Arnold-Janssen strasse 29, Sankt Augustin</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Sankt Augustin</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8852 305X</institution-id><institution-id institution-id-type="GRID">grid.411097.a</institution-id><institution>Department of Pediatric and Adolescents medicine, Medical faculty,</institution><institution>University Hospital of Cologne,</institution></institution-wrap>Kerpener Str. 62, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Kerpener Str. 62, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Magnusson, Bo" sort="Magnusson, Bo" uniqKey="Magnusson B" first="Bo" last="Magnusson">Bo Magnusson</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9241 5705</institution-id><institution-id institution-id-type="GRID">grid.24381.3c</institution-id><institution>Karolinska University Hospital, Pediatric Rheumatology Unit,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Hofer, Michael" sort="Hofer, Michael" uniqKey="Hofer M" first="Michael" last="Hofer">Michael Hofer</name><affiliation wicri:level="3"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2165 4204</institution-id><institution-id institution-id-type="GRID">grid.9851.5</institution-id><institution>Unité Romande d’Immuno-Rhumatologie Pediatrique/Centre Hospitalier Universitaire Vaudois (CHUV), Pediatrie,</institution><institution>University of Lausanne,</institution></institution-wrap>Av Bugnon 46, Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Av Bugnon 46, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0721 9812</institution-id><institution-id institution-id-type="GRID">grid.150338.c</institution-id><institution>University Hospital of Geneva,</institution></institution-wrap>Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Geneva</wicri:regionArea></affiliation></author><author><name sortKey="Alexeeva, Katerina" sort="Alexeeva, Katerina" uniqKey="Alexeeva " first=" Katerina" last="Alexeeva"> Katerina Alexeeva</name><affiliation wicri:level="3"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9216 2496</institution-id><institution-id institution-id-type="GRID">grid.415738.c</institution-id><institution>Federal State Autonomous Institution “National Medical Research Center of Children’s Health” of the Ministry of Health of the Russian Federation,</institution></institution-wrap>LOMONOSOVSKIJ PR-T,2/62, Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>LOMONOSOVSKIJ PR-T,2/62, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff 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Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation,</institution></institution-wrap>Moscow, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Moscow</wicri:regionArea></affiliation></author><author><name sortKey="Panaviene, Violeta" sort="Panaviene, Violeta" uniqKey="Panaviene V" first="Violeta" last="Panaviene">Violeta Panaviene</name><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0567 3159</institution-id><institution-id institution-id-type="GRID">grid.426597.b</institution-id><institution>Vilnius University, Clinic of Children’s Diseases, Vilnius, Lithuania and Children’s Hospital,</institution><institution>Affiliate of Vilnius University Hospital Santariskiu Klinikos,</institution></institution-wrap>Santariskiu, 4, Vilnius, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Santariskiu, 4, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Bader Meunier, Brigitte" sort="Bader Meunier, Brigitte" uniqKey="Bader Meunier B" first="Brigitte" last="Bader-Meunier">Brigitte Bader-Meunier</name><affiliation wicri:level="3"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0593 9113</institution-id><institution-id institution-id-type="GRID">grid.412134.1</institution-id><institution>Université Paris-Descartes, Institut IMAGINE, Centre de référence national pour les Rhumatismes inflammatoires et les maladies Auto-Immunes Systémiques rares de l’Enfant (RAISE), Unité d’Immunologie, Hématologie et Rhumatologie Pediatrique, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris,</institution></institution-wrap>149 Rue De Sevres, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>149 Rue De Sevres, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Anton, Jordi" sort="Anton, Jordi" uniqKey="Anton J" first="Jordi" last="Anton">Jordi Anton</name><affiliation wicri:level="4"><nlm:aff id="Aff12">Hospital Sant Joan de Déu, Universitat de Barcelona, Unidad de Reumatología Pediátrica, Esplugues de Llobregat, Passeig Sant Joan de Deu 2, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Sant Joan de Déu, Universitat de Barcelona, Unidad de Reumatología Pediátrica, Esplugues de Llobregat, Passeig Sant Joan de Deu 2, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Nielsen, Susan" sort="Nielsen, Susan" uniqKey="Nielsen S" first="Susan" last="Nielsen">Susan Nielsen</name><affiliation wicri:level="3"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="GRID">grid.475435.4</institution-id><institution>Juliane Marie Centret, Rigshospitalet, Paediatric Rheumatology Unit,</institution></institution-wrap>Blegdamsvej 9, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Blegdamsvej 9, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="De Benedetti, Fabrizio" sort="De Benedetti, Fabrizio" uniqKey="De Benedetti F" first="Fabrizio" last="De Benedetti">Fabrizio De Benedetti</name><affiliation wicri:level="3"><nlm:aff id="Aff14"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0727 6809</institution-id><institution-id institution-id-type="GRID">grid.414125.7</institution-id><institution>Division of Rheumatology,</institution><institution>IRCCS Ospedale Pediatrico Bambino Gesù,</institution></institution-wrap>Piazza S. Onofrio, 4, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Piazza S. Onofrio, 4, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Kamphuis, Sylvia" sort="Kamphuis, Sylvia" uniqKey="Kamphuis S" first="Sylvia" last="Kamphuis">Sylvia Kamphuis</name><affiliation wicri:level="3"><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">000000040459992X</institution-id><institution-id institution-id-type="GRID">grid.5645.2</institution-id><institution>Sophia Children’s Hospital, Department of Paediatric Rheumatology,</institution><institution>Erasmus University Medical Centre,</institution></institution-wrap>Dr Molewaterplein 60, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Dr Molewaterplein 60, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff16"><institution-wrap><institution-id institution-id-type="ISNI">000000040459992X</institution-id><institution-id institution-id-type="GRID">grid.5645.2</institution-id><institution>Department of Rheumatology,</institution><institution>Erasmus University Medical Centre,</institution></institution-wrap>Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Sta Vi A, Valda" sort="Sta Vi A, Valda" uniqKey="Sta Vi A V" first="Valda" last="Sta Vi A">Valda Sta Vi A</name><affiliation><nlm:aff id="Aff17">Riga Stradins University, Department of Pediatrics, Children University Hospital, Vienibas gatve 45, Riga, LV Latvia</nlm:aff><wicri:noCountry code="subfield">LV Latvia</wicri:noCountry></affiliation></author><author><name sortKey="Tracahana, Maria" sort="Tracahana, Maria" uniqKey="Tracahana M" first="Maria" last="Tracahana">Maria Tracahana</name><affiliation wicri:level="1"><nlm:aff id="Aff18"><institution-wrap><institution-id institution-id-type="ISNI">0000000109457005</institution-id><institution-id institution-id-type="GRID">grid.4793.9</institution-id><institution>Hippokration General Hospital, First Department of pediatrics,</institution><institution>Thessaloniki University School of Medicine,</institution></institution-wrap>Konstantinoupoleos 49, Thessaloniki, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Konstantinoupoleos 49, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Ailioaie, Laura Marinela" sort="Ailioaie, Laura Marinela" uniqKey="Ailioaie L" first="Laura Marinela" last="Ailioaie">Laura Marinela Ailioaie</name><affiliation wicri:level="1"><nlm:aff id="Aff19"><institution-wrap><institution-id institution-id-type="ISNI">0000000419371784</institution-id><institution-id institution-id-type="GRID">grid.8168.7</institution-id><institution>Alexandru Ioan Cuza University of Iasi,</institution></institution-wrap>V. Lupu str.nr. 62, Iasi, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>V. Lupu str.nr. 62, Iasi</wicri:regionArea><wicri:noRegion>Iasi</wicri:noRegion></affiliation></author><author><name sortKey="Tsitsami, Elena" sort="Tsitsami, Elena" uniqKey="Tsitsami E" first="Elena" last="Tsitsami">Elena Tsitsami</name><affiliation wicri:level="3"><nlm:aff id="Aff20"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2155 0800</institution-id><institution-id institution-id-type="GRID">grid.5216.0</institution-id><institution>Aghia Sophia Childrens Hospital, First Department of Pediatrics,</institution><institution>University of Athens Medical School,</institution></institution-wrap>Thivon 1, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Thivon 1, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Klein, Ariane" sort="Klein, Ariane" uniqKey="Klein A" first="Ariane" last="Klein">Ariane Klein</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Asklepios Clinic Sankt Augustin, Arnold-Janssen strasse 29, Sankt Augustin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Asklepios Clinic Sankt Augustin, Arnold-Janssen strasse 29, Sankt Augustin</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Sankt Augustin</settlement></placeName></affiliation></author><author><name sortKey="Minden, Kirsten" sort="Minden, Kirsten" uniqKey="Minden K" first="Kirsten" last="Minden">Kirsten Minden</name><affiliation wicri:level="1"><nlm:aff id="Aff21"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9323 8675</institution-id><institution-id institution-id-type="GRID">grid.418217.9</institution-id><institution>German Rheumatism Research Centre,</institution></institution-wrap>Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Berlin</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff22"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2218 4662</institution-id><institution-id institution-id-type="GRID">grid.6363.0</institution-id><institution>Charité University Medicine,</institution></institution-wrap>Charitéplatz 1, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charitéplatz 1, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Foeldvari, Ivan" sort="Foeldvari, Ivan" uniqKey="Foeldvari I" first="Ivan" last="Foeldvari">Ivan Foeldvari</name><affiliation wicri:level="3"><nlm:aff id="Aff23">Hamburg Centre for Pediatric and Adolescent Rheumatology, Dehnhaide 120, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hamburg Centre for Pediatric and Adolescent Rheumatology, Dehnhaide 120, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Haas, Johannes Peter" sort="Haas, Johannes Peter" uniqKey="Haas J" first="Johannes Peter" last="Haas">Johannes Peter Haas</name><affiliation wicri:level="1"><nlm:aff id="Aff24"><institution-wrap><institution-id institution-id-type="GRID">grid.500039.f</institution-id><institution>German Center for Pediatric and Adolescent Rheumatology, Deutsches Zentrum für Kinder- und Jugendrheumatologie, Zentrum für Schmerztherapie junger Menschen,</institution></institution-wrap>Gehfeldstrasse 24, Garmisch-Partenkirchen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gehfeldstrasse 24, Garmisch-Partenkirchen</wicri:regionArea><wicri:noRegion>Garmisch-Partenkirchen</wicri:noRegion><wicri:noRegion>Garmisch-Partenkirchen</wicri:noRegion><wicri:noRegion>Garmisch-Partenkirchen</wicri:noRegion></affiliation></author><author><name sortKey="Klotsche, Jens" sort="Klotsche, Jens" uniqKey="Klotsche J" first="Jens" last="Klotsche">Jens Klotsche</name><affiliation wicri:level="1"><nlm:aff id="Aff21"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9323 8675</institution-id><institution-id institution-id-type="GRID">grid.418217.9</institution-id><institution>German Rheumatism Research Centre,</institution></institution-wrap>Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Berlin</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff22"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2218 4662</institution-id><institution-id institution-id-type="GRID">grid.6363.0</institution-id><institution>Charité University Medicine,</institution></institution-wrap>Charitéplatz 1, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charitéplatz 1, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Horne, Anna Carin" sort="Horne, Anna Carin" uniqKey="Horne A" first="Anna Carin" last="Horne">Anna Carin Horne</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9241 5705</institution-id><institution-id institution-id-type="GRID">grid.24381.3c</institution-id><institution>Karolinska University Hospital, Pediatric Rheumatology Unit,</institution></institution-wrap>Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Consolaro, Alessandro" sort="Consolaro, Alessandro" uniqKey="Consolaro A" first="Alessandro" last="Consolaro">Alessandro Consolaro</name><affiliation wicri:level="1"><nlm:aff id="Aff25">IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, via Gaslini 5, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, via Gaslini 5, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff26"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2151 3065</institution-id><institution-id institution-id-type="GRID">grid.5606.5</institution-id><institution>Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI),</institution><institution>Università degli Studi di Genova,</institution></institution-wrap>Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Genoa</wicri:regionArea></affiliation></author><author><name sortKey="Bovis, Francesca" sort="Bovis, Francesca" uniqKey="Bovis F" first="Francesca" last="Bovis">Francesca Bovis</name><affiliation wicri:level="1"><nlm:aff id="Aff2">IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa</wicri:regionArea><wicri:noRegion>16147 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Bagnasco, Francesca" sort="Bagnasco, Francesca" uniqKey="Bagnasco F" first="Francesca" last="Bagnasco">Francesca Bagnasco</name><affiliation wicri:level="1"><nlm:aff id="Aff2">IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa</wicri:regionArea><wicri:noRegion>16147 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Pistorio, Angela" sort="Pistorio, Angela" uniqKey="Pistorio A" first="Angela" last="Pistorio">Angela Pistorio</name><affiliation wicri:level="1"><nlm:aff id="Aff27">IRCCS Istituto Giannina Gaslini, Servizio di Epidemiologia e Biostatistica, via Gaslini 5, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Servizio di Epidemiologia e Biostatistica, via Gaslini 5, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Martini, Alberto" sort="Martini, Alberto" uniqKey="Martini A" first="Alberto" last="Martini">Alberto Martini</name><affiliation wicri:level="1"><nlm:aff id="Aff28">IRCCS Istituto Giannina Gaslini, Direzione Scientifica, via Gaslini 5, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Direzione Scientifica, via Gaslini 5, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Wulffraat, Nico" sort="Wulffraat, Nico" uniqKey="Wulffraat N" first="Nico" last="Wulffraat">Nico Wulffraat</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0620 3132</institution-id><institution-id institution-id-type="GRID">grid.417100.3</institution-id><institution>Department of Pediatric Immunology and Rheumatology,</institution><institution>Wilhelmina Children’s Hospital,</institution></institution-wrap>Lundlaan, 6 PO box 85090, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Lundlaan, 6 PO box 85090, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Ruperto, Nicolino" sort="Ruperto, Nicolino" uniqKey="Ruperto N" first="Nicolino" last="Ruperto">Nicolino Ruperto</name><affiliation wicri:level="1"><nlm:aff id="Aff2">IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Via Gaslini, 5, 16147 Genoa</wicri:regionArea><wicri:noRegion>16147 Genoa</wicri:noRegion></affiliation></author></analytic><series><title level="j">Arthritis Research & Therapy</title><idno type="ISSN">1478-6354</idno><idno type="eISSN">1478-6362</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">The availability of methotrexate and the introduction of multiple biological agents have revolutionized the treatment of juvenile idiopathic arthritis (JIA). Several international and national drug registries have been implemented to accurately monitor the long-term safety/efficacy of these agents. This report aims to present the combined data coming from Pharmachild/PRINTO registry and the national registries from Germany (BiKeR) and Sweden.</p></sec><sec><title>Methods</title><p id="Par2">Descriptive statistics was used for demographic, clinical data, drug exposure, adverse events (AEs) and events of special interest (ESIs). For the Swedish register, AE data were not available.</p></sec><sec><title>Results</title><p id="Par3">Data from a total of 15,284 patients were reported: 8274 (54%) from the Pharmachild registry and 3990 (26%) and 3020 (20%) from the German and the Swedish registries, respectively. Pharmachild children showed a younger age (median of 5.4 versus 7.6 years) at JIA onset and shorter disease duration at last available visit (5.3 versus 6.1–6.8) when compared with the other registries. The most frequent JIA category was the rheumatoid factor–negative polyarthritis (range of 24.6–29.9%). Methotrexate (61–84%) and etanercept (24%–61.8%) were the most frequently used synthetic and biologic disease-modifying anti-rheumatic drugs (DMARDs), respectively. There was a wide variability in glucocorticoid use (16.7–42.1%). Serious AEs were present in 572 (6.9%) patients in Pharmachild versus 297 (7.4%) in BiKeR. Infection and infestations were the most frequent AEs (29.4–30.1%) followed by gastrointestinal disorders (11.5–19.6%). The most frequent ESIs were infections (75.3–89%).</p></sec><sec><title>Conclusions</title><p id="Par4">This article is the first attempt to present a very large sample of data on JIA patients from different national and international registries and represents the first proposal for data merging as the most powerful tool for future analysis of safety and effectiveness of immunosuppressive therapies in JIA.</p></sec><sec><title>Registry registration</title><p id="Par5">The Pharmachild registry is registered at <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov">ClinicalTrials.gov</ext-link> (<ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/">NCT01399281</ext-link>) and at the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP) (<ext-link ext-link-type="uri" xlink:href="http://www.encepp.eu/encepp/viewResource.htm?id=19362">http://www.encepp.eu/encepp/viewResource.htm?id=19362</ext-link>). The BiKeR registry is registered at ENCePP (<ext-link ext-link-type="uri" xlink:href="http://www.encepp.eu/encepp/viewResource.htm?id=20591">http://www.encepp.eu/encepp/viewResource.htm?id=20591</ext-link>).</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (10.1186/s13075-018-1780-z) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ravelli, A" uniqKey="Ravelli A">A Ravelli</name></author><author><name sortKey="Martini, A" uniqKey="Martini A">A Martini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruperto, N" uniqKey="Ruperto N">N Ruperto</name></author><author><name sortKey="Levinson, Je" uniqKey="Levinson J">JE Levinson</name></author><author><name sortKey="Ravelli, A" uniqKey="Ravelli A">A Ravelli</name></author><author><name sortKey="Shear, Es" uniqKey="Shear 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McMahon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beukelman, T" uniqKey="Beukelman T">T Beukelman</name></author><author><name sortKey="Xie, F" uniqKey="Xie F">F Xie</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Baddley, Jw" uniqKey="Baddley J">JW Baddley</name></author><author><name sortKey="Delzell, E" uniqKey="Delzell E">E Delzell</name></author><author><name sortKey="Grijalva, Cg" uniqKey="Grijalva C">CG Grijalva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nordstrom, Bl" uniqKey="Nordstrom B">BL Nordstrom</name></author><author><name sortKey="Mines, D" uniqKey="Mines D">D Mines</name></author><author><name sortKey="Gu, Y" uniqKey="Gu Y">Y Gu</name></author><author><name sortKey="Mercaldi, C" uniqKey="Mercaldi C">C Mercaldi</name></author><author><name sortKey="Aquino, P" uniqKey="Aquino P">P Aquino</name></author><author><name sortKey="Harrison, Mj" uniqKey="Harrison M">MJ Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernatsky, S" uniqKey="Bernatsky S">S Bernatsky</name></author><author><name sortKey="Rosenberg, Am" uniqKey="Rosenberg A">AM Rosenberg</name></author><author><name sortKey="Oen, Kg" uniqKey="Oen K">KG Oen</name></author><author><name sortKey="Duffy, Cm" uniqKey="Duffy C">CM Duffy</name></author><author><name sortKey="Ramsey Goldman, R" uniqKey="Ramsey Goldman R">R Ramsey-Goldman</name></author><author><name sortKey="Labrecque, J" uniqKey="Labrecque J">J Labrecque</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lionetti, G" uniqKey="Lionetti G">G Lionetti</name></author><author><name sortKey="Kimura, Y" uniqKey="Kimura Y">Y Kimura</name></author><author><name sortKey="Schanberg, L" uniqKey="Schanberg L">L Schanberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davies, R" uniqKey="Davies R">R Davies</name></author><author><name sortKey="Southwood, Tr" uniqKey="Southwood T">TR Southwood</name></author><author><name sortKey="Kearsley Fleet, L" uniqKey="Kearsley Fleet L">L Kearsley-Fleet</name></author><author><name sortKey="Lunt, M" uniqKey="Lunt M">M Lunt</name></author><author><name sortKey="Hyrich, Kl" uniqKey="Hyrich K">KL Hyrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kearsley Fleet, L" uniqKey="Kearsley Fleet L">L Kearsley-Fleet</name></author><author><name sortKey="Davies, R" uniqKey="Davies R">R Davies</name></author><author><name sortKey="Baildam, E" uniqKey="Baildam E">E Baildam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mourao, Af" uniqKey="Mourao A">AF Mourao</name></author><author><name sortKey="Santos, M" uniqKey="Santos M">M Santos</name></author><author><name sortKey="Melo Gomes, Ja" uniqKey="Melo Gomes J">JA Melo-Gomes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sauvain, Mj" uniqKey="Sauvain M">MJ Sauvain</name></author><author><name sortKey="Schalm, Sb" uniqKey="Schalm S">SB Schalm</name></author><author><name sortKey="Berthet, G" uniqKey="Berthet G">G Berthet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurd, A" uniqKey="Hurd A">A Hurd</name></author><author><name sortKey="Beukelman, T" uniqKey="Beukelman T">T Beukelman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Lituanie</li><li>Pays-Bas</li><li>Roumanie</li><li>Russie</li><li>Suisse</li><li>Suède</li></country><region><li>Attique (région)</li><li>Berlin</li><li>Canton de Vaud</li><li>Catalogne</li><li>District de Cologne</li><li>District fédéral central</li><li>Hambourg</li><li>Hollande-Méridionale</li><li>Hovedstaden</li><li>Latium</li><li>Rhénanie-du-Nord-Westphalie</li><li>Utrecht (province)</li><li>Île-de-France</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Berlin</li><li>Copenhague</li><li>Hambourg</li><li>Lausanne</li><li>Moscou</li><li>Paris</li><li>Rome</li><li>Rotterdam</li><li>Sankt Augustin</li><li>Utrecht</li></settlement><orgName><li>Université de Barcelone</li></orgName></list><tree><noCountry><name sortKey="Sta Vi A, Valda" sort="Sta Vi A, Valda" uniqKey="Sta Vi A V" first="Valda" last="Sta Vi A">Valda Sta Vi A</name></noCountry><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Swart, Joost" sort="Swart, Joost" uniqKey="Swart J" first="Joost" last="Swart">Joost Swart</name></region><name sortKey="Kamphuis, Sylvia" sort="Kamphuis, Sylvia" uniqKey="Kamphuis S" first="Sylvia" last="Kamphuis">Sylvia Kamphuis</name><name sortKey="Kamphuis, Sylvia" sort="Kamphuis, Sylvia" uniqKey="Kamphuis S" first="Sylvia" last="Kamphuis">Sylvia Kamphuis</name><name sortKey="Wulffraat, Nico" sort="Wulffraat, Nico" uniqKey="Wulffraat N" first="Nico" last="Wulffraat">Nico Wulffraat</name></country><country name="Italie"><noRegion><name sortKey="Giancane, Gabriella" sort="Giancane, Gabriella" uniqKey="Giancane G" first="Gabriella" last="Giancane">Gabriella Giancane</name></noRegion><name sortKey="Bagnasco, Francesca" sort="Bagnasco, Francesca" uniqKey="Bagnasco F" first="Francesca" last="Bagnasco">Francesca Bagnasco</name><name sortKey="Bovis, Francesca" sort="Bovis, Francesca" uniqKey="Bovis F" first="Francesca" last="Bovis">Francesca Bovis</name><name sortKey="Consolaro, Alessandro" sort="Consolaro, Alessandro" uniqKey="Consolaro A" first="Alessandro" last="Consolaro">Alessandro Consolaro</name><name sortKey="Consolaro, Alessandro" sort="Consolaro, Alessandro" uniqKey="Consolaro A" first="Alessandro" last="Consolaro">Alessandro Consolaro</name><name sortKey="De Benedetti, Fabrizio" sort="De Benedetti, Fabrizio" uniqKey="De Benedetti F" first="Fabrizio" last="De Benedetti">Fabrizio De Benedetti</name><name sortKey="Martini, Alberto" sort="Martini, Alberto" uniqKey="Martini A" first="Alberto" last="Martini">Alberto Martini</name><name sortKey="Pistorio, Angela" sort="Pistorio, Angela" uniqKey="Pistorio A" first="Angela" last="Pistorio">Angela Pistorio</name><name sortKey="Ruperto, Nicolino" sort="Ruperto, Nicolino" uniqKey="Ruperto N" first="Nicolino" last="Ruperto">Nicolino Ruperto</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Horneff, Gerd" sort="Horneff, Gerd" uniqKey="Horneff G" first="Gerd" last="Horneff">Gerd Horneff</name></region><name sortKey="Foeldvari, Ivan" sort="Foeldvari, Ivan" uniqKey="Foeldvari I" first="Ivan" last="Foeldvari">Ivan Foeldvari</name><name sortKey="Haas, Johannes Peter" sort="Haas, Johannes Peter" uniqKey="Haas J" first="Johannes Peter" last="Haas">Johannes Peter Haas</name><name sortKey="Horneff, Gerd" sort="Horneff, Gerd" uniqKey="Horneff G" first="Gerd" last="Horneff">Gerd Horneff</name><name sortKey="Klein, Ariane" sort="Klein, Ariane" uniqKey="Klein A" first="Ariane" last="Klein">Ariane Klein</name><name sortKey="Klotsche, Jens" sort="Klotsche, Jens" uniqKey="Klotsche J" first="Jens" last="Klotsche">Jens Klotsche</name><name sortKey="Klotsche, Jens" sort="Klotsche, Jens" uniqKey="Klotsche J" first="Jens" last="Klotsche">Jens Klotsche</name><name sortKey="Minden, Kirsten" sort="Minden, Kirsten" uniqKey="Minden K" first="Kirsten" last="Minden">Kirsten Minden</name><name sortKey="Minden, Kirsten" sort="Minden, Kirsten" uniqKey="Minden K" first="Kirsten" last="Minden">Kirsten Minden</name></country><country name="Suède"><noRegion><name sortKey="Magnusson, Bo" sort="Magnusson, Bo" uniqKey="Magnusson B" first="Bo" last="Magnusson">Bo Magnusson</name></noRegion><name sortKey="Horne, Anna Carin" sort="Horne, Anna Carin" uniqKey="Horne A" first="Anna Carin" last="Horne">Anna Carin Horne</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Hofer, Michael" sort="Hofer, Michael" uniqKey="Hofer M" first="Michael" last="Hofer">Michael Hofer</name></region><name sortKey="Hofer, Michael" sort="Hofer, Michael" uniqKey="Hofer M" first="Michael" last="Hofer">Michael Hofer</name></country><country name="Russie"><region name="District fédéral central"><name sortKey="Alexeeva, Katerina" sort="Alexeeva, Katerina" uniqKey="Alexeeva " first=" Katerina" last="Alexeeva"> Katerina Alexeeva</name></region><name sortKey="Alexeeva, Katerina" sort="Alexeeva, Katerina" uniqKey="Alexeeva " first=" Katerina" last="Alexeeva"> Katerina Alexeeva</name></country><country name="Lituanie"><noRegion><name sortKey="Panaviene, Violeta" sort="Panaviene, Violeta" uniqKey="Panaviene V" first="Violeta" last="Panaviene">Violeta Panaviene</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Bader Meunier, Brigitte" sort="Bader Meunier, Brigitte" uniqKey="Bader Meunier B" first="Brigitte" last="Bader-Meunier">Brigitte Bader-Meunier</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Anton, Jordi" sort="Anton, Jordi" uniqKey="Anton J" first="Jordi" last="Anton">Jordi Anton</name></region></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Nielsen, Susan" sort="Nielsen, Susan" uniqKey="Nielsen S" first="Susan" last="Nielsen">Susan Nielsen</name></region></country><country name="Grèce"><noRegion><name sortKey="Tracahana, Maria" sort="Tracahana, Maria" uniqKey="Tracahana M" first="Maria" last="Tracahana">Maria Tracahana</name></noRegion><name sortKey="Tsitsami, Elena" sort="Tsitsami, Elena" uniqKey="Tsitsami E" first="Elena" last="Tsitsami">Elena Tsitsami</name></country><country name="Roumanie"><noRegion><name sortKey="Ailioaie, Laura Marinela" sort="Ailioaie, Laura Marinela" uniqKey="Ailioaie L" first="Laura Marinela" last="Ailioaie">Laura Marinela Ailioaie</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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